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Preventing and exploiting the oncogenic potential of integrating gene vectors
Gene therapy requires efficient gene delivery to cure or prevent disease by modifying the genome of somatic cells. However, gene vectors, which insert themselves into the host genome in order to achieve persistent protein expression, can trigger oncogenesis by upregulating cellular protooncogenes. T...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662574/ https://ncbi.nlm.nih.gov/pubmed/19348042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38831 |
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