Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

Elevated plasma concentrations of HDL cholesterol (HDL-C) are associated with protection from atherosclerotic cardiovascular disease. Animal models indicate that decreased expression of endothelial lipase (LIPG) is inversely associated with HDL-C levels, and genome-wide association studies have iden...

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Detalhes bibliográficos
Main Authors: Edmondson, Andrew C., Brown, Robert J., Kathiresan, Sekar, Cupples, L. Adrienne, Demissie, Serkalem, Manning, Alisa Knodle, Jensen, Majken K., Rimm, Eric B., Wang, Jian, Rodrigues, Amrith, Bamba, Vaneeta, Khetarpal, Sumeet A., Wolfe, Megan L., DerOhannessian, Stephanie, Li, Mingyao, Reilly, Muredach P., Aberle, Jens, Evans, David, Hegele, Robert A., Rader, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662558/
https://ncbi.nlm.nih.gov/pubmed/19287092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37176
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