Transcriptional Repression of the Prosurvival Endoplasmic Reticulum Chaperone GRP78/BIP by E2F1

The endoplasmic reticulum chaperone GRP78/BIP plays a central role in the prosurvival machinery, and its enhanced expression has been implicated in drug resistance, carcinogenesis, and metastasis. E2F1, as part of an antitumor safeguard mechanism, promotes apoptosis regardless of functional p53. Usi...

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Bibliographic Details
Main Authors: Racek, Tomáš, Buhlmann, Sven, Rüst, Franziska, Knoll, Susanne, Alla, Vijay, Pützer, Brigitte M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Transcription, Chromatin, and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662239/
https://ncbi.nlm.nih.gov/pubmed/18840615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803925200
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