Human T-cell Leukemia Virus Type 1 HBZ Protein Bypasses the Targeting Function of Ubiquitination

Human T-cell leukemia virus type 1 (HTLV-1) encodes an antisense viral gene product termed HTLV-1 basic leucine-zipper factor (HBZ). HBZ forms heterodimers with c-Jun, a member of the AP-1 family, and promotes its proteasomal degradation. Although most proteasomal substrates are targeted for degrada...

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Bibliographic Details
Main Authors: Isono, Osamu, Ohshima, Takayuki, Saeki, Yasushi, Matsumoto, Jun, Hijikata, Makoto, Tanaka, Keiji, Shimotohno, Kunitada
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662237/
https://ncbi.nlm.nih.gov/pubmed/18805793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802527200
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