Heat-shock Protein 90 Is Essential for Stabilization of the Hepatitis C Virus Nonstructural Protein NS3

The hepatitis C virus (HCV) is a major cause of chronic liver disease. Here, we report a new and effective strategy for inhibiting HCV replication using 17-allylaminogeldanamycin (17-AAG), an inhibitor of heat-shock protein 90 (Hsp90). Hsp90 is a molecular chaperone with a key role in stabilizing th...

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Bibliografiske detaljer
Main Authors: Ujino, Saneyuki, Yamaguchi, Saori, Shimotohno, Kunitada, Takaku, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652275/
https://ncbi.nlm.nih.gov/pubmed/19150985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806452200
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