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Tyrosine Residues as Redox Cofactors in Human Hemoglobin: IMPLICATIONS FOR ENGINEERING NONTOXIC BLOOD SUBSTITUTES

Respiratory proteins such as myoglobin and hemoglobin can, under oxidative conditions, form ferryl heme iron and protein-based free radicals. Ferryl myoglobin can safely be returned to the ferric oxidation state by electron donation from exogenous reductants via a mechanism that involves two distinc...

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Detalhes bibliográficos
Main Authors: Reeder, Brandon J., Grey, Marie, Silaghi-Dumitrescu, Radu-Lucian, Svistunenko, Dimitri A., Bülow, Leif, Cooper, Chris E., Wilson, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662160/
https://ncbi.nlm.nih.gov/pubmed/18728007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804709200
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