CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1(Cdt2) Pathway during S Phase and after UV Irradiation

Previous reports showed that chromatin-associated PCNA couples DNA replication with Cul4-DDB1(Cdt2)-dependent proteolysis of the licensing factor Cdt1. The CDK inhibitor p21, another PCNA-binding protein, is also degraded both in S phase and after UV irradiation. Here we show that p21 is degraded by...

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Autors principals: Nishitani, Hideo, Shiomi, Yasushi, Iida, Hiroka, Michishita, Masato, Takami, Toshihiro, Tsurimoto, Toshiki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662008/
https://ncbi.nlm.nih.gov/pubmed/18703516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806045200
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