Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

During hematopoiesis, myeloid cell leukemia-1 (MCL-1) mediates the survival of bone marrow progenitors and lymphocytes. However, its requirement during myeloid cell differentiation, development, and effector function is less clear. Lineage-specific deletion of MCL-1 in myeloid precursors results in...

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Bibliographic Details
Main Authors: Steimer, Desiree A., Boyd, Kelli, Takeuchi, Osamu, Fisher, Jill K., Zambetti, Gerard P., Opferman, Joseph T.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Phagocytes, Granulocytes, and Myelopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661864/
https://ncbi.nlm.nih.gov/pubmed/19064728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-159145
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