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FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis

FLIP is a well-established suppressor of death receptor-mediated apoptosis. To define its essential in vivo role in myeloid cells, we generated and characterized mice with Flip conditionally deleted in the myeloid lineage. Myeloid specific Flip-deficient mice exhibited growth retardation, premature...

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Detalhes bibliográficos
Main Authors: Huang, Qi-Quan, Perlman, Harris, Huang, Zan, Birkett, Robert, Kan, Lixin, Agrawal, Hemant, Misharin, Alexander, Gurbuxani, Sandeep, Crispino, John D., Pope, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012591/
https://ncbi.nlm.nih.gov/pubmed/20724542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-252841
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