MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaks

Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structures at DNA double-strand breaks (DSBs). These DSB targeting events are essential for BRCA1-dependent DNA damage response-induced checkpoint and repair func...

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Autors principals: Shao, Genze, Patterson-Fortin, Jeffrey, Messick, Troy E., Feng, Dan, Shanbhag, Niraj, Wang, Yingqun, Greenberg, Roger A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2009
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661612/
https://ncbi.nlm.nih.gov/pubmed/19261746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1739609
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