MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaks

Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structures at DNA double-strand breaks (DSBs). These DSB targeting events are essential for BRCA1-dependent DNA damage response-induced checkpoint and repair func...

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Hlavní autoři: Shao, Genze, Patterson-Fortin, Jeffrey, Messick, Troy E., Feng, Dan, Shanbhag, Niraj, Wang, Yingqun, Greenberg, Roger A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2009
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661612/
https://ncbi.nlm.nih.gov/pubmed/19261746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1739609
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