β-Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform

OBJECTIVE: Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible liver-specific insulin receptor knockout mouse (iLIRKO). RESEARCH DESIGN AND METHODS:...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Escribano, Oscar, Guillén, Carlos, Nevado, Carmen, Gómez-Hernández, Almudena, Kahn, C. Ronald, Benito, Manuel
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2009
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661585/
https://ncbi.nlm.nih.gov/pubmed/19136656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0551
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars