Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

Among the main complications associated with obesity are insulin resistance and altered glucose and lipid metabolism within the liver. It has previously been described that insulin receptor isoform A (IRA) favors glucose uptake and glycogen storage in hepatocytes compared with isoform B (IRB), impro...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Lopez-Pastor, Andrea Raposo, Gomez-Hernandez, Almudena, Diaz-Castroverde, Sabela, Gonzalez-Aseguinolaza, Gloria, Gonzalez-Rodriguez, Agueda, Garcia, Gema, Fernandez, Silvia, Escribano, Oscar, Benito, Manuel
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398497/
https://ncbi.nlm.nih.gov/pubmed/30642871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.036186
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