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Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment

Multiple hippocampal processes and cognitive functions change with aging or Alzheimer's disease, but the potential triggers of these aging cascades are not well understood. Here, we quantified hippocampal expression profiles and behavior across the adult lifespan to identify early aging changes...

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Autors principals: Kadish, Inga, Thibault, Olivier, Blalock, Eric M., Chen, Kuey-C., Gant, John C., Porter, Nada M., Landfield, Philip W.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661568/
https://ncbi.nlm.nih.gov/pubmed/19211887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4599-08.2009
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