Reversal of Aging-Related Neuronal Ca(2+) Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus

Brain Ca(2+) regulatory processes are altered during aging, disrupting neuronal, and cognitive functions. In hippocampal pyramidal neurons, the Ca(2+)-dependent slow afterhyperpolarization (sAHP) exhibits an increase with aging, which correlates with memory impairment. The increased sAHP results fro...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Gant, John C., Chen, Kuey-Chu, Kadish, Inga, Blalock, Eric M., Thibault, Olivier, Porter, Nada M., Landfield, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2015
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518058/
https://ncbi.nlm.nih.gov/pubmed/26224869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1248-15.2015
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares