Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria

BACKGROUND: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolat...

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Hauptverfasser: Pearce, Richard J., Pota, Hirva, Evehe, Marie-Solange B., Bâ, El-Hadj, Mombo-Ngoma, Ghyslain, Malisa, Allen L., Ord, Rosalynn, Inojosa, Walter, Matondo, Alexandre, Diallo, Diadier A., Mbacham, Wilfred, van den Broek, Ingrid V., Swarthout, Todd D., Getachew, Asefaw, Dejene, Seyoum, Grobusch, Martin P., Njie, Fanta, Dunyo, Samuel, Kweku, Margaret, Owusu-Agyei, Seth, Chandramohan, Daniel, Bonnet, Maryline, Guthmann, Jean-Paul, Clarke, Sian, Barnes, Karen I., Streat, Elizabeth, Katokele, Stark T., Uusiku, Petrina, Agboghoroma, Chris O., Elegba, Olufunmilayo Y., Cissé, Badara, A-Elbasit, Ishraga E., Giha, Hayder A., Kachur, S. Patrick, Lynch, Caroline, Rwakimari, John B., Chanda, Pascalina, Hawela, Moonga, Sharp, Brian, Naidoo, Inbarani, Roper, Cally
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661256/
https://ncbi.nlm.nih.gov/pubmed/19365539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1000055
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