Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria

BACKGROUND: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolat...

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Main Authors: Pearce, Richard J., Pota, Hirva, Evehe, Marie-Solange B., Bâ, El-Hadj, Mombo-Ngoma, Ghyslain, Malisa, Allen L., Ord, Rosalynn, Inojosa, Walter, Matondo, Alexandre, Diallo, Diadier A., Mbacham, Wilfred, van den Broek, Ingrid V., Swarthout, Todd D., Getachew, Asefaw, Dejene, Seyoum, Grobusch, Martin P., Njie, Fanta, Dunyo, Samuel, Kweku, Margaret, Owusu-Agyei, Seth, Chandramohan, Daniel, Bonnet, Maryline, Guthmann, Jean-Paul, Clarke, Sian, Barnes, Karen I., Streat, Elizabeth, Katokele, Stark T., Uusiku, Petrina, Agboghoroma, Chris O., Elegba, Olufunmilayo Y., Cissé, Badara, A-Elbasit, Ishraga E., Giha, Hayder A., Kachur, S. Patrick, Lynch, Caroline, Rwakimari, John B., Chanda, Pascalina, Hawela, Moonga, Sharp, Brian, Naidoo, Inbarani, Roper, Cally
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661256/
https://ncbi.nlm.nih.gov/pubmed/19365539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1000055
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