The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics

BACKGROUND: The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr and dhps gene mutations are known to be associated with sulphadoxine/pyrimethamine (SP) resistance. OBJECTIVE: To investigate...

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Main Authors: A-Elbasit, Ishraga E, Alifrangis, Michael, Khalil, Insaf F, Bygbjerg, Ib C, Masuadi, Emad M, Elbashir, Mustafa I, Giha, Hayder A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971711/
https://ncbi.nlm.nih.gov/pubmed/17686173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-6-108
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