The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics

BACKGROUND: The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr and dhps gene mutations are known to be associated with sulphadoxine/pyrimethamine (SP) resistance. OBJECTIVE: To investigate...

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Détails bibliographiques
Auteurs principaux: A-Elbasit, Ishraga E, Alifrangis, Michael, Khalil, Insaf F, Bygbjerg, Ib C, Masuadi, Emad M, Elbashir, Mustafa I, Giha, Hayder A
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2007
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971711/
https://ncbi.nlm.nih.gov/pubmed/17686173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-6-108
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