Restoration of contractility in hyperhomocysteinemia by cardiac-specific deletion of NMDA-R1

Homocysteine (HCY) activated mitochondrial matrix metalloproteinase-9 and led to cardiomyocyte dysfunction, in part, by inducing mitochondrial permeability (MPT). Treatment with MK-801 [N-methyl-d-aspartate (NMDA) receptor antagonist] ameliorated the HCY-induced decrease in myocyte contractility. Ho...

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Main Authors: Moshal, Karni S., Kumar, Munish, Tyagi, Neetu, Mishra, Paras K., Metreveli, Naira, Rodriguez, Walter E., Tyagi, Suresh C.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660230/
https://ncbi.nlm.nih.gov/pubmed/19181966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00750.2008
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