Perilobar nephrogenic rests are non-obligate molecular genetic precursor lesions of IGF2-associated Wilms tumours

PURPOSE: Perilobar nephrogenic rests (PLNRs) are abnormally persistent foci of embryonal immature blastema that have been associated with dysregulation at the 11p15 locus by genetic/epigenetic means, and are thought to be precursor lesions of Wilms tumour. The precise genomic events are, however, la...

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Main Authors: Vuononvirta, Raisa, Sebire, Neil J., Dallosso, Anthony R., Reis-Filho, Jorge S., Williams, Richard D., Mackay, Alan, Fenwick, Kerry, Grigoriadis, Anita, Ashworth, Alan, Pritchard-Jones, Kathy, Brown, Keith W., Vujanic, Gordan M., Jones, Chris
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659869/
https://ncbi.nlm.nih.gov/pubmed/19047088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1620
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