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Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity
In humans, NKG2D is an activating receptor on NK cells and a costimulatory receptor on certain T cells and plays a central role in mediating immune responses in autoimmune diseases, infectious diseases, and cancer. Monoclonal antibodies that antagonize or agonize immune responses mediated by human N...
Uloženo v:
| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659651/ https://ncbi.nlm.nih.gov/pubmed/18809410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.008 |
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