Loss of Metal Ions, Disulfide Reduction and Mutations Related to Familial ALS Promote Formation of Amyloid-Like Aggregates from Superoxide Dismutase

Mutations in the gene encoding Cu-Zn superoxide dismutase (SOD1) are one of the causes of familial amyotrophic lateral sclerosis (FALS). Fibrillar inclusions containing SOD1 and SOD1 inclusions that bind the amyloid-specific dye thioflavin S have been found in neurons of transgenic mice expressing m...

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Detalhes bibliográficos
Main Authors: Oztug Durer, Zeynep A., Cohlberg, Jeffrey A., Dinh, Phong, Padua, Shelby, Ehrenclou, Krista, Downes, Sean, Tan, James K., Nakano, Yoko, Bowman, Christopher J., Hoskins, Jessica L., Kwon, Chuhee, Mason, Andrew Z., Rodriguez, Jorge A., Doucette, Peter A., Shaw, Bryan F., Valentine, Joan Selverstone
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659422/
https://ncbi.nlm.nih.gov/pubmed/19325915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005004
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