Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth

The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development...

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Autores principales: Rezgui, Dellel, Williams, Christopher, Savage, Sharon A, Prince, Stuart N, Zaccheo, Oliver J, Jones, E Yvonne, Crump, Matthew P, Hassan, A Bassim
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Endocrinology 2009
Materias:
Regular papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659294/
https://ncbi.nlm.nih.gov/pubmed/19208780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JME-08-0154
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