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Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1

The telomeric protein TRF1 negatively regulates telomere length by inhibiting telomerase access at the telomere termini, suggesting that the protein level of TRF1 at telomeres is tightly regulated. Regulation of TRF1 protein abundance is essential for proper telomere function and occurs primarily th...

詳細記述

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書誌詳細
主要な著者: Her, Yoon Ra, Chung, In Kwon
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659214/
https://ncbi.nlm.nih.gov/pubmed/19164295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806702200
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