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Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1
The telomeric protein TRF1 negatively regulates telomere length by inhibiting telomerase access at the telomere termini, suggesting that the protein level of TRF1 at telomeres is tightly regulated. Regulation of TRF1 protein abundance is essential for proper telomere function and occurs primarily th...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659214/ https://ncbi.nlm.nih.gov/pubmed/19164295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806702200 |
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