Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1

The telomeric protein TRF1 negatively regulates telomere length by inhibiting telomerase access at the telomere termini, suggesting that the protein level of TRF1 at telomeres is tightly regulated. Regulation of TRF1 protein abundance is essential for proper telomere function and occurs primarily th...

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Bibliografske podrobnosti
Main Authors: Her, Yoon Ra, Chung, In Kwon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659214/
https://ncbi.nlm.nih.gov/pubmed/19164295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806702200
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