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Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT
Telomere homeostasis is regulated by telomerase and a collection of associated proteins. Telomerase is, in turn, regulated by post-translational modifications of the rate-limiting catalytic subunit hTERT. Here we show that disruption of Hsp90 by geldanamycin promotes efficient ubiquitination and pro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1074314/ https://ncbi.nlm.nih.gov/pubmed/15805468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1289405 |
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