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Suppression of hPOT1 in diploid human cells results in an hTERT dependant alteration of telomere length dynamics
POT1 is a 3′ telomeric single stranded overhang binding protein that has been implicated in chromosome end protection, the regulation of telomerase function and defining the 5′ chromosome terminus. In human cancer cells that exhibit constitutive hTERT activity, hPOT1 exerts control over telomere len...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2741145/ https://ncbi.nlm.nih.gov/pubmed/18922974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0070 |
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