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Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae

The mitochondrial cytochrome bc(1) complex is an essential respiratory enzyme in oxygen-utilizing eukaryotic cells. Its core subunit, cytochrome b, contains two sites, center P and center N, that participate in the electron transfer activity of the bc(1) complex and that can be blocked by specific i...

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Detalles Bibliográficos
Main Authors: Ding, Martina G., di Rago, Jean-Paul, Trumpower, Bernard L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659206/
https://ncbi.nlm.nih.gov/pubmed/19179332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809278200
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