The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB

Inhibitors of the ubiquitin-proteasome system (UPSIs) promote apoptosis of cancer cells and show encouraging anti-tumor activities in vivo. In this study, we evaluated the death activities of two different UPSIs: bortezomib and the isopeptidase inhibitor G5. To unveil whether these compounds elicit...

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Detalhes bibliográficos
Main Authors: Fontanini, Alessandra, Foti, Carmela, Potu, Harish, Crivellato, Enrico, Maestro, Roberta, Bernardi, Paolo, Demarchi, Francesca, Brancolini, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659195/
https://ncbi.nlm.nih.gov/pubmed/19139105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806113200
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