Phosphorylation of Adaptor Protein–2 μ2 Is Essential for Na(+),K(+)-ATPase Endocytosis in Response to Either G Protein–Coupled Receptor or Reactive Oxygen Species

Activation of G protein–coupled receptor by dopamine and hypoxia-generated reactive oxygen species promote Na(+),K(+)-ATPase endocytosis. This effect is clathrin dependent and involves the activation of protein kinase C (PKC)-ζ and phosphorylation of the Na(+),K(+)-ATPase α-subunit. Because the inco...

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Main Authors: Chen, Zongpei, Krmar, Rafael T., Dada, Laura, Efendiev, Riad, Leibiger, Ingo B., Pedemonte, Carlos H., Katz, Adrian I., Sznajder, Jacob I., Bertorello, Alejandro M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658693/
https://ncbi.nlm.nih.gov/pubmed/16498080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0044OC
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