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G protein-coupled receptors regulate Na(+),K(+)-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin

Inhibition of Na(+),K(+)-ATPase (NKA) activity in renal epithelial cells by activation of G protein-coupled receptors is mediated by phosphorylation of the catalytic α-subunit followed by endocytosis of active molecules. We examined whether agonists that counteract this effect do so by dephosphoryla...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ogimoto, Goichi, Yudowski, Guillermo A., Barker, Christopher J., Köhler, Martin, Katz, Adrian I., Féraille, Eric, Pedemonte, Carlos H., Berggren, Per-Olof, Bertorello, Alejandro M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16223/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716725/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.060025597
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