G protein-coupled receptors regulate Na(+),K(+)-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin

Inhibition of Na(+),K(+)-ATPase (NKA) activity in renal epithelial cells by activation of G protein-coupled receptors is mediated by phosphorylation of the catalytic α-subunit followed by endocytosis of active molecules. We examined whether agonists that counteract this effect do so by dephosphoryla...

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Main Authors: Ogimoto, Goichi, Yudowski, Guillermo A., Barker, Christopher J., Köhler, Martin, Katz, Adrian I., Féraille, Eric, Pedemonte, Carlos H., Berggren, Per-Olof, Bertorello, Alejandro M.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC16223/
https://ncbi.nlm.nih.gov/pubmed/10716725
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