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Protein Kinase A Activity Controls the Regulation of T-type Ca(V)3.2 Channels by Gβγ Dimers

Low voltage-activated (LVA), T-type, calcium channels mediate diverse biological functions and are inhibited by Gβγ dimers, yet the molecular events required for channel inhibition remain unknown. Here, we identify protein kinase A (PKA) as a molecular switch that allows Gβ(2)γx dimers to effect vol...

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Détails bibliographiques
Auteurs principaux: Hu, Changlong, DePuy, Seth D., Yao, Junlan, McIntire, William E., Barrett, Paula Q.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658042/
https://ncbi.nlm.nih.gov/pubmed/19131331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808049200
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