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A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca(2+) release in muscle fibers of Y522S RyR1 knock-in mice
Malignant hyperthermia (MH) is a life-threatening hypermetabolic condition caused by dysfunctional Ca(2+) homeostasis in skeletal muscle, which primarily originates from genetic alterations in the Ca(2+) release channel (ryanodine receptor, RyR1) of the sarcoplasmic reticulum (SR). Owing to its phys...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657461/ https://ncbi.nlm.nih.gov/pubmed/19246389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812661106 |
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