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Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold
A new, highly efficient, all-solid-phase synthesis of argifin, a natural product cyclic pentapeptide chitinase inhibitor, is reported. The synthesis features attachment of an orthogonally protected Asp residue to the solid support and assembly of the linear peptide chain by Fmoc SPPS prior to cyclis...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657367/ https://ncbi.nlm.nih.gov/pubmed/19109670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b815077j |
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