The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate.

Family 18 chitinases are attractive targets for the development of new inhibitors with chemotherapeutic potential against fungi, insects and protozoan/nematodal parasites. Although several inhibitors have been identified, these are based on complex chemistry, which hampers iterative structure-based...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Houston, Douglas R, Eggleston, Ian, Synstad, Bjørnar, Eijsink, Vincent G H, van Aalten, Daan M F
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222990/
https://ncbi.nlm.nih.gov/pubmed/12323074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021034
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