EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer

INTRODUCTION: PolycombGroup (PcG) proteins maintain gene repression through histone modifications and have been implicated in stem cell regulation and cancer. EZH2 is part of Polycomb Repressive Complex 2 (PRC2) and trimethylates H3K27. This histone mark recruits the BMI1-containing PRC1 that silenc...

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Main Authors: Pietersen, Alexandra M, Horlings, Hugo M, Hauptmann, Michael, Langerød, Anita, Ajouaou, Abderrahim, Cornelissen-Steijger, Paulien, Wessels, Lodewijk F, Jonkers, Jos, Vijver, Marc J van de, van Lohuizen, Maarten
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656906/
https://ncbi.nlm.nih.gov/pubmed/19099573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2214
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