Cardiac Myosin Binding Protein-C Phosphorylation in a “Humanized” Mouse Heart

BACKGROUND: Cardiac myosin binding protein-C (cMyBP-C) phosphorylation modulates cardiac contractility. When expressed in cMyBP-C null (cMyBP-C((t/t))) hearts, a cMyBP-C phosphomimetic (cMyBP-C(AllP+)), rescued cardiac dysfunction and protected the hearts from ischemic-reperfusion (I/R) injury. Howe...

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Main Authors: Sadayappan, Sakthivel, Gulick, James, Klevitsky, Raisa, Lorenz, John N., Sargent, Michelle, Molkentin, Jeffery D., Robbins, Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656413/
https://ncbi.nlm.nih.gov/pubmed/19237661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.798983
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