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Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates cardiac contractility. However, the mechanisms by which cMyBP-C phosphorylation increases contractile kinetics have not been fully elucidated. In this study, we tested the hypothesis that phosphorylation of cMyBP-C releases my...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: McNamara, James W., Singh, Rohit R., Sadayappan, Sakthivel
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575167/
https://ncbi.nlm.nih.gov/pubmed/31142654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821660116
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