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Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

NLRP1 (NLR family, pyrin domain-containing 1) is a contributor to innate immunity involved in intracellular sensing of pathogens, as well as danger signals related to cell injury. NLRP1 is one of the core components of caspase-1-activating platforms termed “inflammasomes,” which are involved in prot...

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Bibliografske podrobnosti
Main Authors: Faustin, Benjamin, Chen, Ya, Zhai, Dayong, Negrate, Gaelle Le, Lartigue, Lydia, Satterthwait, Arnold, Reed, John C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656183/
https://ncbi.nlm.nih.gov/pubmed/19223583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809414106
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