Blinded Independent Central Review of Progression-Free Survival in Phase III Clinical Trials: Important Design Element or Unnecessary Expense?

Progression-free survival is an important end point in advanced disease settings. Blinded independent central review (BICR) of progression in randomized clinical trials has been advocated to control bias that might result from errors in progression assessments. However, although BICR lessens some po...

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Detalhes bibliográficos
Main Authors: Dodd, Lori E., Korn, Edward L., Freidlin, Boris, Jaffe, C. Carl, Rubinstein, Lawrence V., Dancey, Janet, Mooney, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2008
Assuntos:
Statistics in Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654812/
https://ncbi.nlm.nih.gov/pubmed/18669467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.16.1711
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