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Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
KRASis the most frequently mutatedrasfamily member in lung carcinomas1,2, whereasHRASmutations are common in tumours from stratified epithelia such as bladder or skin (www.sanger.ac.uk/genetics/CGP/cosmic/). Using a mouse model (HrasKI)3 in which theHrascoding sequence was inserted into theKraslocus...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654781/ https://ncbi.nlm.nih.gov/pubmed/18758463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.211 |
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