Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

BACKGROUND: Activation of the liver × receptors (LXRs) by exogenous ligands stimulates the degradation of β-amyloid 1–42 (Aβ42), a peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD). The oxidized cholesterol products (oxysterols), 24-hydroxycholesterol (24-OHC) an...

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Auteurs principaux: Prasanthi, Jaya RP, Huls, Amber, Thomasson, Sarah, Thompson, Alex, Schommer, Eric, Ghribi, Othman
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654562/
https://ncbi.nlm.nih.gov/pubmed/19126211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-1
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