Pharmacodynamic-Guided Modified Continuous Reassessment Method–Based, Dose-Finding Study of Rapamycin in Adult Patients With Solid Tumors

PURPOSE: Pharmacodynamic studies are frequently incorporated into phase I trials, but it is uncommon that they guide dose selection. We conducted a dose selection study with daily rapamycin (sirolimus) in patients with solid tumors employing a modified continuous reassessment method (mCRM) using rea...

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Autores principales: Jimeno, Antonio, Rudek, Michelle A., Kulesza, Peter, Ma, Wen Wee, Wheelhouse, Jenna, Howard, Anna, Khan, Yasmin, Zhao, Ming, Jacene, Heather, Messersmith, Wells A., Laheru, Daniel, Donehower, Ross C., Garrett-Mayer, Elizabeth, Baker, Sharyn D., Hidalgo, Manuel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Clinical Oncology 2008
Materias:
Phase I and Clinical Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654371/
https://ncbi.nlm.nih.gov/pubmed/18757332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.16.2347
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