The SCF(Slimb) ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the mechanisms underlying this block to reduplication are unclear. Genetic analyses have suggested an involvement for Skp/Cullin/F box (SCF)-class ubiquitin ligases in this proc...

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Bibliographic Details
Main Authors: Rogers, Gregory C., Rusan, Nasser M., Roberts, David M., Peifer, Mark, Rogers, Stephen L.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2009
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654306/
https://ncbi.nlm.nih.gov/pubmed/19171756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200808049
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