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Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation

Centrosome overduplication promotes mitotic abnormalities, invasion and tumorigenesis. Cells regulate the number of centrosomes by limiting centriole duplication to once per cell cycle. The orthogonal orientation between a mother and a daughter centriole, established at the time of centriole duplica...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Shukla, Anil, Kong, Dong, Sharma, Meena, Magidson, Valentin, Loncarek, Jadranka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560806/
https://ncbi.nlm.nih.gov/pubmed/26293378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9077
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