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Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation

Centrosome overduplication promotes mitotic abnormalities, invasion and tumorigenesis. Cells regulate the number of centrosomes by limiting centriole duplication to once per cell cycle. The orthogonal orientation between a mother and a daughter centriole, established at the time of centriole duplica...

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Publicat a:Nat Commun
Autors principals: Shukla, Anil, Kong, Dong, Sharma, Meena, Magidson, Valentin, Loncarek, Jadranka
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560806/
https://ncbi.nlm.nih.gov/pubmed/26293378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9077
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