PTCH1 (+/−) Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts

Gorlin's or nevoid basal cell carcinoma syndrome (NBCCS) causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. Mutations in the tumor suppressor gene PTCH1 are responsible for this autosomal dominant syndrome. In NBCCS patients, as in the general population,...

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Bibliografiska uppgifter
Huvudupphovsmän: Valin, Alexandre, Barnay-Verdier, Stéphanie, Robert, Thomas, Ripoche, Hugues, Brellier, Florence, Chevallier-Lagente, Odile, Avril, Marie-Françoise, Magnaldo, Thierry
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654107/
https://ncbi.nlm.nih.gov/pubmed/19287498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004818
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