Basal Cell Carcinoma in Gorlin’s Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?

Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Gache, Yannick, Brellier, Florence, Rouanet, Sophie, Al-Qaraghuli, Sahar, Goncalves-Maia, Maria, Burty-Valin, Elodie, Barnay, Stéphanie, Scarzello, Sabine, Ruat, Martial, Sevenet, Nicolas, Avril, Marie-Françoise, Magnaldo, Thierry
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687848/
https://ncbi.nlm.nih.gov/pubmed/26694869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145369
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