Basal Cell Carcinoma in Gorlin’s Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?

Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gache, Yannick, Brellier, Florence, Rouanet, Sophie, Al-Qaraghuli, Sahar, Goncalves-Maia, Maria, Burty-Valin, Elodie, Barnay, Stéphanie, Scarzello, Sabine, Ruat, Martial, Sevenet, Nicolas, Avril, Marie-Françoise, Magnaldo, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687848/
https://ncbi.nlm.nih.gov/pubmed/26694869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145369
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