PTCH1 (+/−) Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts

Gorlin's or nevoid basal cell carcinoma syndrome (NBCCS) causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. Mutations in the tumor suppressor gene PTCH1 are responsible for this autosomal dominant syndrome. In NBCCS patients, as in the general population,...

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Main Authors: Valin, Alexandre, Barnay-Verdier, Stéphanie, Robert, Thomas, Ripoche, Hugues, Brellier, Florence, Chevallier-Lagente, Odile, Avril, Marie-Françoise, Magnaldo, Thierry
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2009
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654107/
https://ncbi.nlm.nih.gov/pubmed/19287498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004818
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